HyperKinetiKx SPR Product Suite for Pre-clinical Drug Discovery
HyperKinetiKx is SPOC’s flagship high-throughput SPR suite, delivering ultra-high-resolution kinetic data (Kx = ka, kd, KD, t½), residue-level epitope insights and AI-ready datasets for biologics discovery. Thousands of scFv, VHH, Fab, protein, and peptide variants are synthesized directly on-chip, to output picomolar resolution kinetics at unprecedented scale.
HyperKinetiKx SPR Product Suite for Pre-clinical Drug Discovery
HyperKinetiKx is SPOC’s flagship high-throughput SPR suite, delivering ultra-high-resolution kinetic data (Kx = ka, kd, KD, t½), residue-level epitope insights and AI-ready datasets for biologics discovery. Thousands of scFv, VHH, Fab, protein, and peptide variants are synthesized directly on-chip, to output picomolar resolution kinetics at unprecedented scale.
HyperKinetiKx AffiRank
HyperKinetiKx AffiRank redefines lead selection for biologics discovery. Unlike conventional assays, it multiplexes up to 1,152 antibody, protein, or peptide variants per SPR chip to generate complete kinetic datasets (ka, kd, KD, residence time) in a single run. Libraries can be tested against target isoforms, PTMs, or mutational variants to rapidly profile selectivity and specificity. This compresses weeks of low-throughput assays into days and reduces cost per datapoint dramatically. AffiRank delivers objective kinetic parameter‑based rankings tuned to your modality’s performance window, to down select by highest affinity, fastest on-rates, or longest residence times.
HyperKinetiKx AffiRank
HyperKinetiKx AffiRank redefines lead selection for biologics discovery. Unlike conventional assays, it multiplexes up to 1,152 antibody, protein, or peptide variants per SPR chip to generate complete kinetic datasets (ka, kd, KD, residence time) in a single run. Libraries can be tested against target isoforms, PTMs, or mutational variants to rapidly profile selectivity and specificity. This compresses weeks of low-throughput assays into days and reduces cost per datapoint dramatically. AffiRank delivers objective kinetic parameter‑based rankings tuned to your modality’s performance window, to down select by highest affinity, fastest on-rates, or longest residence times.
HyperKinetiKx AffiBoost
HyperKinetiKx AffiBoost turns affinity maturation into a high‑throughput, on‑chip DBTL loop: 192 – 1,152 diversified variants are synthesized on a single SPOC biosensor and profiled in a single injection of target, yielding full Kx kinetics (ka/kd/KD) and residence‑time data, in hours. The kinetic data sets stream straight into your statistical or AI models, instantly flagging tighter binders and steering the next mutational round – slashing cost, reagents, and timelines. Bonus: the deeply annotated variant matrix equips your IP team with residue-level “contact fingerprints,” enabling post-Amgen v. Sanofi claims with robust enablement support.
HyperKinetiKx AffiBoost
HyperKinetiKx AffiBoost turns affinity maturation into a high‑throughput, on‑chip DBTL loop: 192 – 1,152 diversified variants are synthesized on a single SPOC biosensor and profiled in a single injection of target, yielding full Kx kinetics (ka/kd/KD) and residence‑time data, in hours. The kinetic data sets stream straight into your statistical or AI models, instantly flagging tighter binders and steering the next mutational round – slashing cost, reagents, and timelines. Bonus: the deeply annotated variant matrix equips your IP team with residue-level “contact fingerprints,” enabling post-Amgen v. Sanofi claims with robust enablement support.
HyperKinetiKx EpiScope
HyperKinetiKx EpiScope compresses epitope mapping and binning into a single on-chip workflow. The same 1,152-variant SPOC library ranked in AffiRank is screened against selected binders to generate real-time competition data across every clone. By sequentially challenging the on-chip library with 96 – 384 soluble candidates, EpiScope produces a complete epitope-overlap matrix without re-spotting or labeling, reducing labor and reagent use by over 70%. The result: only variants with functionally relevant epitopes advance into potency, developability, or diagnostic panel design.
HyperKinetiKx EpiScope
HyperKinetiKx EpiScope compresses epitope mapping and binning into a single on-chip workflow. The same 1,152-variant SPOC library ranked in AffiRank is screened against selected binders to generate real-time competition data across every clone. By sequentially challenging the on-chip library with 96 – 384 soluble candidates, EpiScope produces a complete epitope-overlap matrix without re-spotting or labeling, reducing labor and reagent use by over 70%. The result: only variants with functionally relevant epitopes advance into potency, developability, or diagnostic panel design.
HyperKinetiKx AminoMap
HyperKinetiKx AminoMap pinpoints residue-level determinants of binding, mapping epitopes at single amino-acid resolution by flowing your leads across a deep‑mutational‑scan of the target on a SPOC chip. In one afternoon, you get real‑time SPR readouts and ΔΔG fingerprints that separate “look‑alike” antibodies, expose mechanistic nuances, and guide smarter developability and potency decisions. Seamlessly paired with AffiRank and EpiScope, AminoMap completes a rapid on‑chip workflow from kinetic ranking to amino-acid level insight.
Catalog chips coming 2026.
HyperKinetiKx AminoMap
HyperKinetiKx AminoMap pinpoints residue-level determinants of binding, mapping epitopes at single amino-acid resolution by flowing your leads across a deep‑mutational‑scan of the target on a SPOC chip. In one afternoon, you get real‑time SPR readouts and ΔΔG fingerprints that separate “look‑alike” antibodies, expose mechanistic nuances, and guide smarter developability and potency decisions. Seamlessly paired with AffiRank and EpiScope, AminoMap completes a rapid on‑chip workflow from kinetic ranking to amino-acid level insight.
Catalog chips coming 2026.
HyperKinetiKx ReactiScan
HyperKinetiKx ReactiScan builds on the same 1,152 variant on-chip library ranked in AffiRank, by sequentially flowing polyreactivity reagents for real-time SPR biosensing of interactions across the library. Weak, fast-off interactions often missed by endpoint assays show as distinct SPR traces, producing a polyreactivity map that quantifies nonspecific burden. This guides CDR re-engineering, chemotype pruning, or formulation optimization. Collapse weeks of serial assays into a single experiment to de‑risk developability, manufacturability and safety liabilities.
HyperKinetiKx ReactiScan
HyperKinetiKx ReactiScan builds on the same 1,152 variant on-chip library ranked in AffiRank, by sequentially flowing polyreactivity reagents for real-time SPR biosensing of interactions across the library. Weak, fast-off interactions often missed by endpoint assays show as distinct SPR traces, producing a polyreactivity map that quantifies nonspecific burden. This guides CDR re-engineering, chemotype pruning, or formulation optimization. Collapse weeks of serial assays into a single experiment to de‑risk developability, manufacturability and safety liabilities.
For more information on the SPOC platform, get in touch:
Contact Us
1600 Adams Drive
Suite 236
Menlo Park, CA 94025
7201 E Henkel Way
Suite 285
Scottsdale, AZ 85255
480-219-9506
For more information on the SPOC platform, get in touch:
Contact Us
1600 Adams Drive
Suite 236
Menlo Park, CA 94025
7201 E Henkel Way
Suite 285
Scottsdale, AZ 85255
480-219-9506
Privacy & Conditions
All rights reserved © 2024
