HyperKinetiKx SPR Assay Suite for Pre-clinical Drug Discovery
HyperKinetiKx is SPOC’s flagship high‑throughput SPR suite, delivering real‑time kinetics (Kx = ka, kd, KD, t1/2), residue‑level epitope insight, and AI‑ready datasets across the biologics discovery pipeline. On‑chip synthesis of thousands of folded proteins yields sub‑picomolar affinity resolution in one integrated workflow.
HyperKinetiKx SPR Assay Suite for Pre-clinical Drug Discovery
HyperKinetiKx is SPOC’s flagship high‑throughput SPR suite, delivering real‑time kinetics (Kx = ka, kd, KD, t1/2), residue‑level epitope insight, and AI‑ready datasets across the biologics discovery pipeline. On‑chip synthesis of thousands of folded proteins yields sub‑picomolar affinity resolution in one integrated workflow.
HyperKinetiKx AffiRank
HyperKinetiKx AffiRank is your lead‑selection engine for antibodies, mini‑proteins, and peptides—multiplexing up to 1,152 variants on a single SPOC chip to capture full Kx kinetics (kon/koff/KD) and residence‑time profiles in one run. By collapsing weeks of serial SPR work into hours and slashing reagent use and cost per datapoint, AffiRank delivers objective, kinetics‑based rankings tuned to your modality’s performance window. Identify the tightest binders, map functional epitopes, and advance only the winners—fast.
HyperKinetiKx AffiRank
HyperKinetiKx AffiRank is your lead‑selection engine for antibodies, mini‑proteins, and peptides—multiplexing up to 1,152 variants on a single SPOC chip to capture full Kx kinetics (kon/koff/KD) and residence‑time profiles in one run. By collapsing weeks of serial SPR work into hours and slashing reagent use and cost per datapoint, AffiRank delivers objective, kinetics‑based rankings tuned to your modality’s performance window. Identify the tightest binders, map functional epitopes, and advance only the winners—fast.
HyperKinetiKx AffiBoost
HyperKinetiKx AffiBoost turns affinity maturation into a high‑throughput, on‑chip DBTL loop: 192–1,152 diversified variants are synthesized on a single SPOC biosensor and profiled in one antigen injection, yielding full Kx kinetics (kon/koff/KD) and residence‑time data in hours. Those kinetics stream straight into your AI or statistical models, instantly flagging tighter binders and steering the next mutation round—slashing cost, reagents, and timelines.Bonus: the deeply annotated variant matrix arms your IP team with residue‑level “contact fingerprints” to craft post‑Amgen v. Sanofi–ready patent claims.
HyperKinetiKx AffiBoost
HyperKinetiKx AffiBoost turns affinity maturation into a high‑throughput, on‑chip DBTL loop: 192–1,152 diversified variants are synthesized on a single SPOC biosensor and profiled in one antigen injection, yielding full Kx kinetics (kon/koff/KD) and residence‑time data in hours. Those kinetics stream straight into your AI or statistical models, instantly flagging tighter binders and steering the next mutation round—slashing cost, reagents, and timelines.Bonus: the deeply annotated variant matrix arms your IP team with residue‑level “contact fingerprints” to craft post‑Amgen v. Sanofi–ready patent claims.
HyperKinetiKx EpiScope
HyperKinetiKx EpiScope turns epitope mapping and binning into an hours-long, one‑chip workflow—using the same 1,152‑member SPOC library ranked in AffiRank to capture real‑time competition data across every binder. By sequentially challenging the immobilized library with 96–384 soluble candidates, EpiScope builds a complete epitope‑overlap matrix without re-spotting or labeling, cutting labor and reagents by >80%. Advance only the variants that hit functionally relevant epitopes—and streamline downstream potency, developability, and diagnostic panel design.
HyperKinetiKx EpiScope
HyperKinetiKx EpiScope turns epitope mapping and binning into an hours-long, one‑chip workflow—using the same 1,152‑member SPOC library ranked in AffiRank to capture real‑time competition data across every binder. By sequentially challenging the immobilized library with 96–384 soluble candidates, EpiScope builds a complete epitope‑overlap matrix without re-spotting or labeling, cutting labor and reagents by >80%. Advance only the variants that hit functionally relevant epitopes—and streamline downstream potency, developability, and diagnostic panel design.
HyperKinetiKx AminoMap
HyperKinetiKx AminoMap pinpoints exactly which residues matter—mapping epitopes at single–amino‑acid resolution by flowing your leads across a deep‑mutational‑scan of the target on a SPOC chip. In one afternoon, you get real‑time SPR readouts and ΔΔG fingerprints that separate “look‑alike” antibodies, expose mechanistic nuances, and guide smarter developability and potency decisions. Seamlessly paired with AffiRank and EpiScope, AminoMap completes a rapid, one‑chip path from kinetic ranking to sub‑molecular insight.
Catalog chips coming 2026-2027.
HyperKinetiKx AminoMap
HyperKinetiKx AminoMap pinpoints exactly which residues matter—mapping epitopes at single–amino‑acid resolution by flowing your leads across a deep‑mutational‑scan of the target on a SPOC chip. In one afternoon, you get real‑time SPR readouts and ΔΔG fingerprints that separate “look‑alike” antibodies, expose mechanistic nuances, and guide smarter developability and potency decisions. Seamlessly paired with AffiRank and EpiScope, AminoMap completes a rapid, one‑chip path from kinetic ranking to sub‑molecular insight.
Catalog chips coming 2026-2027.
HyperKinetiKx ReactiScan
HyperKinetiKx ReactiScan flags polyreactivity early by flowing your leads across a curated on‑chip library of hundreds to thousands of off‑target proteins while SPR captures real‑time kinetics for every interaction. Weak, fast‑off binders that end-point assays miss show up as distinct traces, generating an off‑target heat map that ranks nonspecific burden and guides CDR re‑engineering, chemotype pruning, or formulation tweaks. Collapse weeks of serial assays into a single experiment and de‑risk developability, manufacturability, and safety before they derail your program.
HyperKinetiKx ReactiScan
HyperKinetiKx ReactiScan flags polyreactivity early by flowing your leads across a curated on‑chip library of hundreds to thousands of off‑target proteins while SPR captures real‑time kinetics for every interaction. Weak, fast‑off binders that end-point assays miss show up as distinct traces, generating an off‑target heat map that ranks nonspecific burden and guides CDR re‑engineering, chemotype pruning, or formulation tweaks. Collapse weeks of serial assays into a single experiment and de‑risk developability, manufacturability, and safety before they derail your program.
For more information on the SPOC platform, get in touch:
Contact Us
1600 Adams Drive
Suite 236
Menlo Park, CA 94025
7201 E Henkel Way
Suite 285
Scottsdale, AZ 85255
480-219-9506
For more information on the SPOC platform, get in touch:
Contact Us
1600 Adams Drive
Suite 236
Menlo Park, CA 94025
7201 E Henkel Way
Suite 285
Scottsdale, AZ 85255
480-219-9506
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